Myelin-associated inhibitors in axonal growth after CNS injury
نویسندگان
چکیده
منابع مشابه
Improving axonal growth and functional recovery after experimental spinal cord injury by neutralizing myelin associated inhibitors.
Injuries of the spinal cord often result in an irretrievable loss of motor and sensory functions of all body parts situated below the lesion site. Functional recovery is restricted mainly due to the limited regeneration and plasticity of injured axons in the adult central nervous system. Over the last few years different experimental approaches have led to axonal growth and functional benefits ...
متن کاملP78: Depakine Improve Axonal Growth In Vitro and In Vivo after Spinal Cord Injury
لطفاً به چکیده انگلیسی مراجعه شود.
متن کاملExtracellular regulators of axonal growth in the adult central nervous system.
Robust axonal growth is required during development to establish neuronal connectivity. However, stable fibre patterns are necessary to maintain adult mammalian central nervous system (CNS) function. After adult CNS injury, factors that maintain axonal stability limit the recovery of function. Extracellular molecules play an important role in preserving the stability of the adult CNS axons and ...
متن کاملp78: depakine improve axonal growth in vitro and in vivo after spinal cord injury
central nervous system axons fail to regenerate after spinal cord injury (sci), partially due to the accumulation of extracellular matrix molecules in the lesion and formation of the glial scar. depakine, as known as histone deacetylase inhibitor, has neuroprotective effects. this study evaluated the histological changes (cavitation and axon regeneration) after sci associated with (following ad...
متن کاملMAG, myelin and overcoming growth inhibition in the CNS
While neurons in the central nervous system (CNS) have the capacity to regenerate their axons after injury, they fail to do so, in part because regeneration is limited by growth inhibitory proteins present in CNS myelin. Myelin-associated glycoprotein (MAG) was the first myelin-derived growth inhibitory protein identified, and its inhibitory activity was initially elucidated in 1994 independent...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Opinion in Neurobiology
سال: 2014
ISSN: 0959-4388
DOI: 10.1016/j.conb.2014.02.012